The dark side of APOE e4: unravelling amyloid-independent effects in AD.

 
   Lead Investigator:    Giulia Quattrini
   Institution      :    IRCCS Saint John of God Clinical Research Centre
   E-Mail           :    gquattrini@fatebenefratelli.eu
   Proposal ID      :    1290



   Proposal Description:
   The objective of this study is to investigate which amyloid-independent mechanisms link APOE e4 to AD-related alterations appearance and progression. According to our preliminary data, we have developed the hypothesis that we will test in the present project where increasing amyloid deposition is just one among several indipendent mechanisms by which the major AD genetic determinant acts. Moreover, we speculate that APOE e4 amyloid-independent effects (i.e. on inflammation or metabolism) impact AD pathology earlier than those amyloid-dependent.